Ageing and Cardiovascular System A Multidisciplinary Approach

Venerdì 22 novembre, alle ore 14.30, presso l'Aula Magna del Dipartimento di Farmacia (Via Bonanno Pisano 12) avrà luogo il convegno dal titolo "Ageing and Cardiovascular System: A Multidisciplinary Approach".

L'evento è organizzato dal Centro Interdipartimentale di Ricerca di Biologia e Patologia dell'Invecchiamento, con patrocinio dell'Ateneo e dell'Università Italo-Francese.

La partecipazione è gratuita. Per motivi organizzativi è gradita la pre-registrarzione da effettuarsi inviando una e-mail al Dott. Andrea Stoccoro (Questo indirizzo email è protetto dagli spambots. È necessario abilitare JavaScript per vederlo.) entro lunedì 11 Novembre.

Rationale and objectives

Addressing the ageing of the general population is a global challenge that involves both developed and developing countries. It is therefore crucial to ensure healthy, active and sustainable ageing for national health systems by keeping the elderly population in optimal health and preventing the onset of cardiometabolic diseases. Ageing, oxidative stress (OS) and inflammation play a key role in the development of cardiovascular diseases (CVD), the main cause of morbidity and mortality worldwide. The concept of “Oxi-Inflamm-Aging” is based on the observation that low-grade oxidative and inflammatory processes, commonly seen in the elderly and others, contribute to CV risk. Furthermore, perivascular adipose tissue (PVAT), which is in close physical contact with the vessel, is crucial in preserving healthy vascular function. Its premature ageing is associated with tissue metabolic dysfunction and pro-inflammatory phenotype. Understanding the mechanisms linking inflammation and ageing, as well as those implicated in endothelial dysfunction, OS, genomic instability and PVAT alteration could reveal new therapeutic targets to sustain cardiovascular “health” and provide options for addressing the ageing population worldwide. The conference, with the participation of leading experts, aims to examine and understand the key processes of ageing at the cardiovascular and metabolic levels and to identify pharmacological strategies to prevent and slow them down.

Scientific organizing Comitee:

Fabio Coppedè, University of Pisa
Gabriella Cavallini, University of Pisa
Eugenia Belcastro, University of Pisa

Programma

14.30
Welcoming reception

14.45
Introduction and Institutional Greetings

Moderators:
Dr. Eugenia Belcastro, University of Pisa
Pr. Gabriella Cavallini, University of Pisa

15.15
Targeting Senescent Endothelial Cells to Improve Vascular Health
Pr. Valérie B. Schini-Kerth, University of Strasbourg

15:45
Metformin-Isothiocyanate (Met-ITC): A New Multitarget Pharmacological Approach in the Prevention of Endothelial Dysfunction Associated with Diabetes
Pr. Alma Martelli, University of Pisa

16:15
Coffee Break

16.30
Aging of Perivascular Tissue Associated with Meta-Inflammatory Shifts
Dr. Alessandro Mengozzi, University of Pisa

17.00
Discussion and Conclusions