Unipi Team Leader: Prof. Roger Fuoco – Dip. di Chimica e Chimica Industriale

The aim of the KardiaTool project is to translate a laboratory proven concept of a saliva biosensor to the clinical practice for addressing the priority needs in personalized HF diagnostics and therapy monitoring at the point of care.

The KardiaTool platform includes: (i) An easy to use portable POC device (KardiaPOC) with a disposable Lab-on-a-Chip (LOC), for the non-invasive, rapid and accurate qualitative and quantitative assessment of HF biomarkers, from saliva samples. KardiaPOC device will integrate a variety of sensors, actuators, Microelectromechanical systems (MEMS), micro-electronics, bio-chemicals and functionalized magnetic nanoparticles (MNPs), onto a disposable, low cost LOC. (ii) A decision support software (KardiaSoft) based on predictive modelling techniques, that analyzes the POC data and other patient’s data, directly added by the healthcare professionals, and delivers information related to HF diagnosis and therapy monitoring.

The innovation lays in the incorporation of four novel saliva biomarkers that have been proven in a laboratory setting and bring a new promising concept for addressing the priority needs of the clinical arena. KardiaPOC will provide the capability of simultaneously extracting key information from the saliva biomarkers: (i) NT-proBNP, (ii) TNF-a, (iii) Interleukin- 10, (iv) Cortisol. It is expected that identifying a comparable source to blood, for biomarker information, such as saliva, that is cost effective, less invasive, more convenient and acceptable for both patients and healthcare professionals would be beneficial for the healthcare community. The challenge of KardiaTool is: (i) to translate a laboratory proven concept of a saliva biosensor into an MNBS platform, for HF diagnostics and therapy monitoring, at the point of care, following GLP (ii) to validate the MNBS platform through pre-clinical and clinical testing following GCP and (iii) to industrialize the outcomes following GMP towards progress to marketization.

Coordinator
SELENA LABS SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (Poland)

Other participants

• FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS (Greece)
• AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS (Spain)
• UNIVERSITA DI PISA (Italy)
• FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (Germany)
• BIOTRAY (France)
• MICRONIT MICROTECHNOLOGIES BV (Netherlands)
• INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM (Belgium)
• PANEPISTIMIO IOANNINON (Greece)
• VALOTEC (France)
• CONSIGLIO NAZIONALE DELLE RICERCHE (Italy)
• ENACHIP INC (United States)
• UNIVERSITY OF SURREY (United Kingdom)
• UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN (Ireland)
• Start date: 01-11-2017

End date: 30-04-2021

Duration: 48 months

Project cost:  4 999 880,55 euro

Project funding:  4 999 880,55 euro

Unipi quota:  191 250 euro

Call title:  H2020-NMBP-X-KET-2017

Unipi role: partner

Project website: http://www.kardiatool.eu/