Viruses and breast cancer

The Workshop is in the frame of the Regione Toscana research project  “Is breast cancer caused by a virus? Study on the etiological role, pathogenetic mechanisms and spreading of the human mammary tumor virus infection"

Under the auspices of the European Society of Pathology and of Istituto Toscano Tumori. In collaboration with the “Palazzo blu” Foundation

Programma:

APRIL 2, MONDAY

14:00 Welcome Addresses

14:30 Generoso Bevilacqua

Remembering Francesco Squartini, 1927-1992

Session I

CHAIR: JAMES LAWSON, HARALD ZUR HAUSEN

14:45 Harald zur Hausen

Viruses in human cancers: reasons to suspect an involvement of infections in human breast cancer?

15:30 Gertrude Buehring

Could Bovine Leukemia Virus play a role in human breast cancer?

16:15 Discussion

16:30 COFFEE

Session II

CHAIR: GERTRUDE BUEHRING, EZEQUIEL MOISES FUENTES PANANÁ

17:00 Mauro Pistello

The expanding world of polyomaviruses and cancer.

17:30 James Lawson

Multiple viruses in breast cancer: Mouse Mammary Tumor Virus (MMTV), Epstein Barr

Virus (EBV), Human Papilloma Virus (HPV), Bovine Leukemia Virus (BLV).

18:15 Discussion

APRIL 3, TUESDAY

Session III

CHAIR: JACOB HOCHMAN, SUSAN ROSS

9:00 Beatriz Pogo

MMTV in human cancer, an overview

9:45 Brian Salmons, Walter Gunzburg

Past and future perspectives on MMTV

10:30 Discussion

10:45 COFFEE

Session IV

CHAIR: BEATRIZ POGO, ALEXANDER STEWART

11:15 Generoso Bevilacqua, Chiara Maria Mazzanti

MMTV in sporadic and hereditary human breast cancer.

12:00 Jaquelin Dudley

What factors affect MMTV replication in human cells?

12:45 Discussion

13:00 LUNCH

Session V

CHAIR: JAQUELIN DUDLEY, CHIARA MARIA MAZZANTI

14:30 Robert Callahan

Common integration sites for MMTV in mammary tumors and their involvement in

tumorigenesis.

15:15 Susan Ross

MMTV integration site analysis uncovers new pathways involved in breast cancer.

16:00 Discussion

16:15 COFFEE

Session VI

CHAIR: STELLA MELANA, BRIAN SALMONS

16:45 Andrew Mason

Providing definitive proof of MMTV-like viruses in humans: isolation of the human

betaretrovirus and detection of integration sites in patients.

17:30 Jacob Hochman

New insights into tumor growth regulation by the signal peptide of MMTV-env.

18:15 Discussion

APRIL 4, WEDNESDAY

Session VII

CHAIR: WALTER GUNZBURG, ANDREW MASON

9:00 Stella Melana

The host response to HMTV infection

9:45 Ezequiel Moises Fuentes Pananá

Screening of EBV, MMTV and HHV7 sequences in breast cancer samples from Mexico.

10:30 Discussion

10:45 COFFEE

Session VIII

CHAIR: ROBERT CALLAHAN, MAURO PISTELLO

11:15 Alexander Stewart

Breast cancer incidence spikes and mouse population explosions in New South Wales, Australia.

11:45 General Discussion

12:15 Generoso Bevilacqua

General comment and future plans

Speakers:

• Generoso Bevilacqua, University of Pisa and Pisa University Hospital, Italy

• Gertrude Buehring, University of California, Berkeley, CA, USA

• Robert Callahan, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA

• Jaquelin Dudley, University of Texas, Austin, TX, USA

• Ezequiel Moises Fuentes Pananá, Hospital de Pediatría, Mexico City, Mexico

• Walter Gunzburg, University of Veterinary Medicine, Vienna, Austria

• Jacob Hochman, The Hebrew University, Jerusalem, Israel

• James Lawson, University of New South Wales, Sydney, Australia

• Andrew Mason, University of Alberta, Canada

• Chiara Maria Mazzanti, University of Pisa and Pisa University Hospital

• Stella Melana, Mount Sinai School of Medicine, New York, NY, USA

• Mauro Pistello, University of Pisa and Pisa University Hospital, Italy

• Beatriz Pogo, Mount Sinai School of Medicine, New York, NY, USA

• Susan Ross, University of Pennsylvania, Philadelphia, PA, USA

• Brian Salmons, Austrianova Singapore Pte Ltd, Singapore

• Alexander Stewart, University of Ottawa, Ottawa, Canada

• Harald zur Hausen, German Cancer Research Center, Heidelberg, Germany